ADAM J. COOK /the.chempire

        Currently, I work alongside a team of excellent chemists who hope to solve problems in chemical catalysis through the application of modern techniques and technologies. In graduate school, I have explored the use of nickel catalysis in combination with high-throughput chemical techniques in an attempt to activate bonds that have previously been thought to be inert.

     In recent years, I have focused on the activation of strong carbon-oxygen bonds, attempting to utilize unprotected alcohols in deoxygenative functionalization reactions. I have developed a strong interest in the application of physical organic chemistry towards the mechanistic elucidation of transformations, and jump at the chance to use modern technologies towards the synthesis and diversification of pharmaceutically-relevant compounds. 

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     The motto? There is no such thing as "hasn't been discovered", only "hasn't been discovered yet".

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Publications​

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8. Cook, A.; Kassymbek, A.; Vaezghaemi, A.; Barbery, C.; Newman, S. G. An SN1-Approach to Cross-Coupling: Deoxygenative Arylation Facilitated by the B-Silicon Effect. J. Am. Chem. Soc. 2024. 146, 19929-19938.

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DOI: 10.1021/jacs.4c03197

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7. Cook, A.; Newman, S. G. Alcohols as substrates in transition metal-catalyzed arylation, alkylation and related reactions. Chem. Rev. 2024. 124, 6078-6144.

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DOI: 10.1021/acs.chemrev.4c00094

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6. Cook, A.; St. Onge, P.; Newman, S. G. Deoxygenative Suzuki-Miyaura Arylation of Tertiary Alcohols Through Silyl Ethers. Nature Synthesis 2023.

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DOI: 10.1038/s44160-023-00275-w

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5. Cook, A.; Bezaire, M.; Newman, S. G. Nickel-Catalyzed Desulfonylative Olefination of β-Hydroxysulfones. Org. Chem. Front., 2023, 10, 1339-1404.

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DOI: 10.1039/D2QO01999J

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4. St. Onge, P.; Khan, S. I.; Cook, A.; Newman, S. G. Reductive Cleavage of C(sp2)-CF3 Bonds in Trifluoromethylpyridines. Org. Lett., 2023, 25, 1030-1034.

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DOI: 10.1021/acs.orglett.3c00258

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3. Cook, A.; MacLean, H.; St. Onge, P.; Newman, S. G. Nickel-Catalyzed Reductive Deoxygenation of Diverse C-O Bond-Bearing Functional Groups. ACS Catal., 2021, 11, 13337-13347.

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DOI: 10.1021/acscatal.1c03980

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2. Cook, A.; Clément, R.; Newman, S. G. Reaction Screening in Multiwell Plates: High-Throughput Optimization of a Buchwald-Hartwig Amination. Nature Protocols 2021, 16, 1152-1169. 
 

DOI: 10.1038/s41596-020-00452-7

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1. Cook, A.; Prakash, S.; Zheng, Y.-Z.; Newman, S. G. Exhaustive Reduction of Esters Enabled by Nickel Catalysis. J. Am. Chem. Soc. 2020, 142, 8109-8115.

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DOI: 10.1021/jacs.0c02405

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